She’s been a fixture on daytime television for more than two decades, and Oprah Winfrey has announced she’s getting ready to close up shop.

The 55-year-old talk show host will be on the air until September 2011, marking a quarter of a century run for “The Oprah Winfrey Show.”

She explained, “After much prayer and careful thought, I decided that next season, season 25 will be the last season.  I love this show. … This show has been my life and I love it enough to know when it’s time to say goodbye.”

Winfrey continued, “These years with you, our viewers, have enriched my life beyond all measure.  We’ve grown together. You’ve raised your families, had your children. And left a spot for me in the mornings or the afternoons. … I want you all to know my relationship with you is one that I hold very dear.”